PKCβ inhibitor 1

A PKCβ Inhibitor

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库存: 现货

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价格

促销价

数量
500ug

￥1675.00

1340.00

- +
1mg

￥2987.00

2390.00

- +
5mg

￥8637.00

6910.00

- +
10mg

￥14425.00

11540.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx32856
CAS: 257879-35-9
别名: 3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
分子式: C24H21N5O2
分子量: 411.46
纯度: >98%
溶解度: DMSO : 250 mg/mL (607.59 mM)
储存: Store at -20°C
库存: 现货

Background

PKCβ inhibitor is an inhibitor of PKCβ1 and PKCβ2 (IC₅₀s = 21 and 5 nM, respectively).¹ It is selective for PKCβ1 and PKCβ2 over PKCα, PKCε, and PKCγ (IC₅₀s = 331, 2,807, and >1,000 nM, respectively), as well as JAK1, JAK2, and tyrosine kinase 2 (TYK2; IC₅₀s = 770, 3,850, and 2,310 nM, respectively), but also inhibits JAK3 (IC₅₀ = 17 nM).¹,² PKCβ inhibitor (14 ?M) induces apoptosis and inhibits cell cycle progression in 2F7 AIDS-related Burkitt’s lymphoma cells.³

1.Tanaka, M., Sagawa, S., Hoshi, J.-I., et al.Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitorsBioorg. Med. Chem. Lett.14(20)5171-5174(2004) 2.McDonnell, M.E., Bian, H., Wrobel, J., et al.Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitorsBioorg. Med. Chem. Lett.24(4)1116-1121(2014) 3.Saba, N.S., and Levy, L.S.Protein kinase C-beta inhibition induces apoptosis and inhibits cell cycle progression in acquired immunodeficiency syndrome-related non-hodgkin lymphoma cellsJ. Investig. Med.60(1)29-38(2012)