Manzamine A hydrochloride

A β-carboline alkaloid

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1mg

￥2725.00

2180.00

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5mg

￥8637.00

6910.00

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Background

Manzamine A is a β-carboline alkaloid with diverse activities that has been found in marine sponges, including X. ashmorica.¹ It is an inhibitor of glycogen synthase kinase 3β (GSK3β) and cyclin-dependent kinase 5 (CDK5; IC₅₀s = 10.2 and 1.5 μM, respectively).² It inhibits the growth of L5178y mouse lymphoma cells with an ED₅₀ value of 1.8 μg/mL.¹ In an agar diffusion assay, manzamine A inhibits the growth of B. subtilis and S. aureus, but not E. coli bacteria. It reduces the reverse transcriptase (RT) activity in supernatant from HIV-1-infected peripheral blood mononuclear cells (PBMCs; EC₅₀ = 4.2 μM).³ In vivo, manzamine A (100 μmol/kg, i.p.) has antimalarial activity and reduces the amount of P. berghei in infected mice by over 90% relative to the control.⁴ Manzamine A (132 ppm) inhibits the growth of S. littoralis larva by 80% when added to the larval diet.¹

1.Edrada, R.A., Proksch, P., Wray, V., et al.Four new bioactive manzamine-type alkaloids from the Philippine marine sponge Xestospongia ashmoricaJ. Nat. Prod.59(11)1056-1060(1996) 2.Hamann, M., Alonso, D., Martín-Aparicio, E., et al.Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's diseaseJ. Nat. Prod.70(9)1397-1405(2007) 3.Rao, K.V., Donia, M.S., Peng, J., et al.Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseasesJ. Nat. Prod.69(7)1034-1040(2006) 4.Ang, K.K., Holmes, M.J., Higa, T., et al.In vivo antimalarial activity of the beta-carboline alkaloid manzamine AAntimicrob. Agents Chemother.44(6)1645-1649(2000)