TC11 是一种 MCL1 降解剂和 Caspase-9 和 CDK1 激活剂。TC11 作为苯酞酰亚胺衍生物在结构上与免疫调节药物有关。在长时间有丝分裂阻滞期间，TC11 诱导 MCL1 降解导致凋亡性死亡。
TC11 is a MCL1 degradator and Caspase-9 and CDK1 activator. TC11 is structurally related to immunomodulatory drugs as phenylphthalimide derivative. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest[1][2].
Cell Viability Assay[1]
Cell Line:
KMS34 cells
Concentration:
0~30 μM
Incubation Time:
24 hours
Result:
Induced cell death.
Western Blot Analysis[1]
Cell Line:
KMS34 cells
Concentration:
5 μM
Incubation Time:
0~48 hours
Result:
Induced cell death occurs through an apoptotic pathway and downregulated MCL1 expression.
Cell Cycle Analysis[1]
Cell Line:
KMS34 cells
Concentration:
5 μM
Incubation Time:
24 hours
Result:
Induced M arrest.
体内研究(In Vivo)
TC11 (0~30 μM; 24 hours; KMS34 cells) induces cell death in KMS34[1].TC11 (5 μM; 0~48 hours; KMS34 cells) Induces cell death occurs through an apoptotic pathway and downregulates MCL1 expression[1].TC11 (5 μM; 24 hours; KMS34 cells) Induces M arrest[1].
TC11 (0~30 μM; 24 hours; KMS34 cells) induces cell death in KMS34[1].TC11 (5 μM; 0~48 hours; KMS34 cells) Induces cell death occurs through an apoptotic pathway and downregulates MCL1 expression[1].TC11 (5 μM; 24 hours; KMS34 cells) Induces M arrest[1].
[1]. Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020;521(1):252-258.
[2]. Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7(6):e38878.
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