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Vodobatinib

Vodobatinib (K0706, SCO-088, SUN K706, SUN-K0706) is a novel BCR-ABL1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants with IC50s of 167 nM, 154 nM,165 nM and 1967 nM for BCR-ABL1L248R, BCR-

原价

￥1100-8100

价格

￥ 880-6480

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产品引用

货号: ajcx33058
CAS: 1388803-90-4
别名: K0706
分子式: C27H20ClN3O2
分子量: 453.92
纯度: >98%
溶解度: DMSO : 125 mg/mL (275.38 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

Vodobatinib (K0706, SCO-088, SUN K706, SUN-K0706) is a novel BCR-ABL1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants with IC50s of 167 nM, 154 nM,165 nM and 1967 nM for BCR-ABL1L248R, BCR-ABL1Y253H , BCR-ABL1E255V and BCR-ABL1T315I, respectively.

[1] Orlando Antelope, et al. Exp Hematol. 2019 Sep;77:36-40.e2.

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