Fluzoparib

Fluzoparib (SHR3162, HS10160) is a potent Poly (ADP-ribose) polymerase (PARP) inhibitor that shows anti-tumor activity.

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5mg

￥1625.00

1300.00

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10mg

￥2725.00

2180.00

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25mg

￥5400.00

4320.00

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50mg

￥8412.00

6730.00

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100mg

￥12287.00

9830.00

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货号: ajcx33094
CAS: 1358715-18-0
别名: 氟唑帕利; SHR3162; Fuzuloparib
分子式: C22H16F4N6O2
分子量: 472.4
纯度: >98%
溶解度: DMSO : 50 mg/mL (105.84 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

Fluzoparib (SHR3162, HS10160) is a potent Poly (ADP-ribose) polymerase (PARP) inhibitor that shows anti-tumor activity.

All four NSCLC cell lines (A549, H460, H1299, and PC9) shows decreased viability upon exposure to fluzoparib, and the effect is time and dose dependent. Fluzoparib acts synergistically to inhibit cell growth and promote apoptosis among lung cancer cells.[2]

An H460 cell xenograft mouse model is established to study the in vivo effects of fluzoparib and RT on tumor growth and survival. Treatment with RT + fluzoparib more effectively delayed tumor growth than treatment with either RT or fluzoparib individually. When combined with RT, fluzoparib conferres a significant survival benefit with no evidence of toxicity.[2]

[1] Ye Han, et al. Am J Cancer Res. 2019 Mar 1;9(3):608-618. [2] Jing Luo, et al. J Cancer Res Clin Oncol. 2020 Mar;146(3):721-737.