PF-00835231

An inhibitor of SARS-CoV and SARS-CoV-2 Mpro

原价

￥1850-14425

价格

￥ 1480-11540

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库存: 现货

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产品引用

货号: ajcx33118
CAS: 870153-29-0
别名:
分子式: C24H32N4O6
分子量: 472.53
纯度: >98%
溶解度: DMSO : 250 mg/mL (529.07 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

PF-00835231 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 main protease (M^pro), also known as 3C-like protease (3CL^pro; K_is = 4 and 0.27 nM, respectively).¹ It reduces the infectivity of SARS-CoV and common cold human coronavirus 229E (HCoV-229E) in Vero cells (EC₅₀s = 4.8 and 0.09 ?M, respectively).

1.Hoffman, R.L., Kania, R.S., Brothers, M.A., et al.Discovery of ketone-based covalent inhibitors of coronavirus 3CL proteases for the potential therapeutic treatment of COVID-19J. Med. Chem.63(21)12725-12747(2020)

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信号通路

生命科学

有机化学

无机化学

材料科学

PF-00835231

PF-00835231详情

Background