BC1618

An inhibitor of FBXO48

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库存: 现货

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5mg

￥637.00

510.00

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10mg

￥1025.00

820.00

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25mg

￥2025.00

1620.00

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50mg

￥3050.00

2440.00

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100mg

￥4525.00

3620.00

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货号: ajcx33122
CAS: 2222094-18-8
别名:
分子式: C24H24F3NO2
分子量: 415.45
纯度: >98%
溶解度: DMSO : 100 mg/mL (240.70 mM; Need ultrasonic)|Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

BC-1618 is an inhibitor of F-box only protein 48 (FBXO48), an E3 ubiquitin ligase.¹ It is selective for FBXO48 over FBXO30 at 3 ?M. BC-1618 (0.5-10 ?M) increases the levels of phosphorylated AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase (pACC), an AMPK downstream substrate, in HEK293T cells expressing human FBXO48. It induces mitochondrial fission in BEAS-2B cells and autophagy in HEK293A cells expressing GFP-tagged LC3. BC-1618 also inhibits LPS-induced activation of NF-κB in THP-1 cells in a reporter assay and cytokine release in isolated human peripheral blood mononuclear cells (PBMCs). It increases insulin sensitivity in a mouse model of high-fat diet-induced obesity when administered at a dose of 20 mg/kg.

1.Liu, Y., Jurczak, M.J., Lear, T.B., et al.A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistanceNat. Chem. Biol.17(3)298-306(2021)