Molnupiravir

A prodrug form of EIDD-1931

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库存: 现货

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10mg

￥762.00

610.00

- +
25mg

￥987.00

790.00

- +
50mg

￥1625.00

1300.00

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100mg

￥2725.00

2180.00

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200mg

￥4850.00

3880.00

- +
500mg

￥10250.00

8200.00

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1g

￥16562.00

13250.00

- +

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货号: ajcx33176
CAS: 2492423-29-5;2349386-89-4
别名: 莫那比拉韦,EIDD-2801; MK-4482
分子式: C13H19N3O7
分子量: 329.31
纯度: >98%
溶解度: DMSO : 100 mg/mL (303.67 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

Molnupiravir is a prodrug form of the antiviral ribonucleoside analog EIDD-1931 .^1,2 Molnupiravir (500 mg/kg) reduces body weight loss, lung hemorrhage, and lung viral titers, as well as improves pulmonary function in mouse models of severe acute respiratory syndrome coronavirus (SARS-CoV) or Middle East respiratory syndrome coronavirus (MERS-CoV) infection when administered prophylactically at 2 hours pre-infection or therapeutically at 12 hours post-infection.¹ It also reduces shed virus load and fever in ferret models of H1N1 or H3N2 influenza A virus infection when administered at a dose of 100 mg/kg twice per day.²

1.Sheahan, T.P., Sims, A.C., Zhou, S., et al.An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in miceSci. Transl. Med.12(541)eabb5883(2020) 2.Toots, M., Yoon, J.-J., Cox, R.M., et al.Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epitheliaSci. Transl. Med.11(515)eaax5866(2019)