CD532 hydrochloride

An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction

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库存: 现货

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包装

价格

促销价

数量
5mg

￥1300.00

1040.00

- +
10mg

￥2175.00

1740.00

- +
25mg

￥4200.00

3360.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

CD532 is an inhibitor of Aurora A kinase activity (IC₅₀ = 48 nM) and the protein-protein interaction between N-Myc and Aurora A kinase.¹ It also inhibits several cyclin-dependent kinases (CDKs), FGFRs, MEKs, and PDGFRs, as well as FLT3, KIT, and RET at 10 ?M.² CD532 induces degradation of N-Myc in SK-N-BE(2) neuroblastoma cells (EC₅₀ = 223 nM).¹ It prevents S-phase entry in SK-N-BE(2) cells when used at a concentration of 1 ?M.¹ CD532 (25 mg/kg) reduces tumor growth and increases survival in a MYCN-amplified SMS-KCN neuroblastoma mouse xenograft model.

1.Gustafson, W.C., Meyerowitz, J.G., Nekritz, E.A., et al.Drugging MYCN through an allosteric transition in Aurora kinase ACancer Cell26(3)414-427(2014) 2.Lee, J.K., Phillips, J.W., Smith, B.A., et al.N-Myc drives neuroendocrine prostate cancer initiated from human prostate epithelial cellsCancer Cell29(4)536-547(2016)