AKT-IN-6

AKT-IN-6 (Example 13) 是一种有效的 AKT 抑制剂。AKT-IN-6抑制 Akt1、Akt2 和 Akt3， IC50s 分别 < 500nM，来自专利WO201305615A1。

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库存: 现货

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5mg

￥1300.00

1040.00

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10mg

￥2287.00

1830.00

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25mg

￥4525.00

3620.00

- +
50mg

￥7775.00

6220.00

- +

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货号: ajcx33232
CAS: 1430056-54-4
别名:
分子式: C22H20FN5O
分子量: 389.43
纯度: >98%
溶解度: DMSO : 125 mg/mL (320.98 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).

Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2].

[1]. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1.
[2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.