FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhi
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for MAT2A.
FIDAS-3 inhibits Methionine S-adenosyltransferase 2A (MAT2A) activity in S-adenosylmethionine (SAM) synthesis, leading to the inhibition of CRC cell growth.[1]
FIDAS-3 represses the growth of human CRC xenografts in athymic nude mice with no notable effects on body weight.FIDAS-3 represses the growth of human CRC xenografts in athymic nude mice with no notable effects on body weight. [1]
[1] Zhang W, et al. ACS Chem Biol. 2013 Apr 19;8(4):796-803.
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