Ro-0335

An NNRTI and active metabolite of elsulfavirine

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库存: 现货

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5mg

￥1625.00

1300.00

- +
10mg

￥2725.00

2180.00

- +
25mg

￥5937.00

4750.00

- +
50mg

￥10250.00

8200.00

- +
100mg

￥16562.00

13250.00

- +

已选 0 种 0 瓶

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货号: ajcx33298
CAS: 867365-76-2
别名: Ro-0335
分子式: C21H13BrCl2FN3O4S
分子量: 573.22
纯度: >98%
溶解度: DMSO : 250 mg/mL (436.13 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

Ro 0335 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and an active metabolite of the antiviral prodrug elsulfavirine.¹ It inhibits HIV-1 reverse transcriptase in a cell-free assay and the replication of HIV-1 in MT-4 cells (IC₅₀s = 8.1 and 1.1 nM, respectively). Ro 0335 also selectively inhibits human carbonic anhydrase VII (CAVII; K_i = 9.7 nM) over human CAI and CAIII-VI (K_is = >125 nM for all) but also inhibits human CAII, CAIX, CAXII, CAXIII, and CAXIV (K_is = 35.5, 72.1, 62.3, 52.2, and 15.4 nM, respectively).²

1.Javanbakht, H., Ptak, R., G., Chow, E., et al.In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitorAntiviral Res.86(2)212-219(2010) 2.Supuran, C.T., Nocentini, A., Yakubova, E., et al.Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida?) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoformsJ. Enzyme Inhib. Med. Chem.36(1)1056-1060(2021)