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- Janus kinase (JAK)
- 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
A TYK2 inhibitor
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包装价格促销价数量
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5mg￥1625.001300.00- +
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10mg￥2725.002180.00- +
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25mg￥5937.004750.00- +
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- 货号: ajcx33318
- CAS: 1258292-64-6
- 别名:
- 分子式: C16H13Cl2N3O2
- 分子量: 350.2
- 纯度: ＞98%
- 溶解度: DMSO : 62.5 mg/mL (178.47 mM; Need ultrasonic)
- 储存: 4°C, protect from light
- 库存: 现货
Background
GDC-046 is a tyrosine kinase 2 (TYK2) inhibitor (Ki = 4.8 nM).1 It is selective for TYK2 over JAK1, -2, and -3 (Kis = 83.8, 27.6, and 253 nM, respectively). GDC-046 selectively inhibits TYK2-mediated IL-12-induced phosphorylation of STAT4 over JAK1-mediated IL-6-induced phosphorylation of STAT3 and JAK2-mediated erythropoietin-induced phosphorylation of STAT5 in cell-based assays (EC50s = 380, 2,000, and 1,700 nM, respectively).
1.Liang, J., van Abbema, A., Balazs, M., et al.Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitorsJ. Med. Chem.56(11)4521-4536(2013)
