FTO-IN-1 TFA 是一种脂肪和肥胖相关酶 (FTO) 抑制剂，IC50 值 <1 μM。FTO-IN-1 TFA 可用于癌症的研究。详细信息请参考专利文献 WO2018157843A1 中的化合物 32。
FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC50 of <1 μM. FTO-IN-1 TFA can be used for the research of cancer[1].
FTO-IN-1 TFA (50 μM) inhibits FTO enzyme activity by 62% in vitro[1].FTO-IN-1 TFA (50 μM) inhibits the viability of SCLC-21H, RH30 and KP3 cells, with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively[1].
[1]. Yang C, et, al. 2-(substituted benzene matrix) aromatic formate fto inhibitor, preparation method therefor, and applications thereof. WO2018157843A1.
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