Propargyl-PEG4-Br

Propargyl-PEG4-Br 是一种 PROTAC 连接桥，属于 PEG 类。Propargyl-PEG4-Br 可用于合成一系列 PROTAC 分子。Propargyl-PEG4-Br 是一种不可降解 (non-cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

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Background

Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Suzanne AKERS-RODRIGUEZ, et al. Compositions and methods for the treatment of bacterial infections. WO2019126353A2.