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NiCur

NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation o

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￥2175-10250

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￥ 1740-8200

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产品引用

货号: ajcx33346
CAS: N/A
别名:
分子式: C22H16N2O
分子量: 324.38
纯度: >98%
溶解度: DMSO : 50 mg/mL (154.14 mM; ultrasonic and warming and heat to 80°C)
储存: Store at -20°C
库存: 现货

Background

NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter.

[1] Vincek AS, et al. Molecules. 2018 Aug 2;23(8):1930.

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