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  • JR14a
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JR14a

JR14a, a selective and potent human Complement C3a receptor antagonist, which is assessed by inhibition of intracellular calcium release (IC50=10 nM) induced in human monocyte-derived macrophages by C3a, inhibition of β-hexosaminidase secretion (IC50=8 nM

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¥2012-10250
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1610-8200
JR14a的二维码

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  • 货号: ajcx33396
  • CAS: 2411440-41-8
  • 别名:
  • 分子式: C25H26Cl2N4O3S
  • 分子量: 533.47
  • 纯度: >98%
  • 溶解度:
  • 储存: Store at -20°C
  • 库存: 现货

Background

JR14a, a selective and potent human Complement C3a receptor antagonist, which is assessed by inhibition of intracellular calcium release (IC50=10 nM) induced in human monocyte-derived macrophages by C3a, inhibition of β-hexosaminidase secretion (IC50=8 nM) from human LAD2 mast cells degranulated by C3a, and selectivity for human C3aR over C5aR.


[1] Rowley JA, et al. J Med Chem. 2020 Jan 23;63(2):529-541.

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