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- PKD (Protein kinase D)
- Redaporfin
Redaporfin
Redaporfin (LUZ11) 是一种有效的光敏剂，具有直接的抗肿瘤作用，以及对恶性病变的间接免疫依赖性破坏作用。
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包装价格促销价数量
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100mg￥30775.0024620.00- +
- 货号: ajcx33436
- CAS: 1224104-08-8
- 别名: LUZ11; F2BMet
- 分子式: C48H38F8N8O8S4
- 分子量: 1135.11
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
Redaporfin (LUZ11) acts as a potent photosensitizer. Redaporfin causes direct antineoplastic effects as well as indirect immune‐dependent destruction of malignant lesions[1].
The combination photodynamic therapy (PDT) with Redaporfin (5μM) induces a reduction in the abundance of several Golgi apparatus (GA) proteins such as Golgi brefeldin A-resistant guanine nucleotide exchange factor 1 (GBF1), golgin subfamily A member 2 (GOLGA2), and galactosyltransferase 1 (GALT1), as well as that of two ER proteins, eukaryotic translation initiation factor 2-alpha (eIF2α) kinase 3 (EIF2AK3) and protein disulfide-isomerase A3 (PDIA3). In contrast, there is no major decrease in mitochondrial import receptor subunit TOM20 homolog (TOMM20) or in the cytoskeleton protein β-actin[1].
[1]. Lígia C Gomes-da-Silva, et al. Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus. EMBO J. 2018 Jul 2;37(13):e98354.
