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- HSP (Heat shock proteins)
- DDO-5936
DDO-5936
DDO-5936 是一种有效且特异的 Hsp90-Cdc37 PPI 抑制剂。DDO-5936 可用于大肠癌的研究。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥1625.001300.00- +
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10mg￥2825.002260.00- +
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25mg￥6037.004830.00- +
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50mg￥10250.008200.00- +
- 货号: ajcx33460
- CAS: 2355377-13-6
- 别名:
- 分子式: C25H29N5O4S
- 分子量: 495.59
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer[1].
DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47[1].
DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group[1].DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency[1].
[1]. Wang L, et al. Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer. J Med Chem. 2020;63(3):1281-1297.
