AZD5305

AZD5305 is a highly selective and potent inhibitor of PARP1 with an IC50 of 3 nM in wild-type A549 lung cancer cells. AZD5305 shows no or minimal growth inhibitory effects in other cells (IC50s >10μM).

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库存: 现货

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1mg

￥850.00

680.00

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5mg

￥2537.00

2030.00

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10mg

￥4025.00

3220.00

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25mg

￥7975.00

6380.00

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50mg

￥12050.00

9640.00

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100mg

￥18700.00

14960.00

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货号: ajcx33470
CAS: 2589531-76-8
别名: AZD5305
分子式: C22H26N6O2
分子量: 406.48
纯度: >98%
溶解度: DMSO : 41.67 mg/mL (102.51 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

AZD5305 is highly selective inhibitor for PARP1 over other PARP family members, with good secondary pharmacology and physicochemical properties and excellent pharmacokinetics in preclinical species. AZD5305 reduces anti-proliferation effects on human bone marrow progenitor cells in vitro.^[2]

AZD5305 is a potent and selective PARP1 inhibitor and PARP1–DNA trapper with excellent in vivo efficacy in a BRCA mutant HBCx-17 PDX model.^[2]

[1] Natalie Y L Ngoi, et al. Cancer J . 2021 Nov-Dec 01;27(6):521-528. [2] Johannes JW, et al.J Med Chem. 2021 Oct 14;64(19):14498-14512.