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- Hedgehog (Hh)
- SJ6986
SJ6986
A degrader of GSPT1 and GSPT2
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥650.00520.00- +
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10mg￥1037.00830.00- +
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25mg￥2062.001650.00- +
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50mg￥3375.002700.00- +
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100mg￥5287.004230.00- +
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- 货号: ajcx33484
- CAS: 2765625-93-0
- 别名:
- 分子式: C20H14F3N3O7S
- 分子量: 497.4
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
SJ6986 is a degrader of G1 to S phase transition 1 (GSPT1) and GSPT2.1 It reduces the levels of GSPT1 and GSPT2 in MV4-11 cells in a concentration-dependent manner. SJ6986 inhibits proliferation of MV4-11, MHH-CALL-4, MB002, MB004, and HD-MB03 cells (EC50s = 1.5, 0.4, 726, 336, and 3,583 nM, respectively) and reduces the viability of MV4-11 cells endogenously expressing cereblon but not MV4-11 cereblon knockout cells.
1.Nishiguchi, G., Keramatnia, F., Min, J., et al.Identification of potent, selective, and orally bioavailable small-molecule GSPT1/2 degraders from a focused library of cereblon modulatorsJ. Med. Chem.64(11)7296-7311(2021)
