USP7-IN-8

USP7-IN-8 (example 81) 是一种选择性的泛素特异性蛋白酶 7 (USP7) 抑制剂，在 Ub-Rho110 分析中的 IC50 为 1.4 μM。USP7-IN-8 对 USP47 和 USP5 没有活性。USP7-IN-8 具有抗癌作用。

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库存: 现货

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促销价

数量
5mg

￥2175.00

1740.00

- +
10mg

￥3487.00

2790.00

- +
50mg

￥10575.00

8460.00

- +
100mg

￥16025.00

12820.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx33602
CAS: 2009273-60-1
别名:
分子式: C21H21N3O2
分子量: 347.41
纯度: >98%
溶解度: DMSO : 83.33 mg/mL (239.86 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1].

USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].

[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.