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  • Simotinib
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Simotinib

Simotinib 是一种选择性、特异性、口服生物利用度高的 EGFR 酪氨酸激酶抑制剂,IC50 为 19.9 nM。抗肿瘤活性。

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¥3775-11875
价格
3020-9500
Simotinib的二维码

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  • 货号: ajcx33618
  • CAS: 944258-89-3
  • 别名:
  • 分子式: C25H26ClFN4O4
  • 分子量: 500.95
  • 纯度: >98%
  • 溶解度:
  • 储存: Store at -20°C
  • 库存: 现货

Background

Simotinib is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities[1].


Simotinib inhibits in a dose-dependent manner EGFR and the growth of human A431 tumor cells with high expression of EGFR, with no significant activity on other investigated kinases[1].


Simotinib has been shown to exert its antitumor activity by inhibiting EGFR phosphorylation in nude xenograft model[1].


[1]. Hu XS, et al. Safety, tolerability, and pharmacokinetics of simotinib, a novel specific EGFR tyrosine kinase inhibitor, in patients with advanced non-small cell lung cancer: results of a phase Ib trial. Cancer Manag Res. 2019;11:4449-4459. Published 2019 May 13.

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