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  • Teplinovivint
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Teplinovivint

Teplinovivint 是一种有效的 wnt/β-catenin 信号通路抑制剂。Teplinovivint 具有抗炎活性,具有用于肌腱病研究的潜力。

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¥3775-26712
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3020-21370
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  • 货号: ajcx33636
  • CAS: 1428064-91-8
  • 别名:
  • 分子式: C25H26N6O2
  • 分子量: 442.51
  • 纯度: >98%
  • 溶解度: DMSO : 83.33 mg/mL (188.31 mM; Need ultrasonic)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research[1].


Teplinovivint (compound 175; 0.0003-10 μM) inhibits Wnt/p-catenin activity in human colorectal cancecell line (SW480) in a dose-dependent manner (EC50=152.9 nM)[1]. Teplinovivint inhibits SW480 cells (EC50=25 nM) and primary human mesenchymal stem cells (hMSCs; EC50=10.377 μM)[1]. Teplinovivint (5.8, 10.8, 21.7, 41.7, 83.3, 166.6, 333.3, 750 nM) induced the expression of SCXA, TenacinC and Tenomodulin, in a dose-dependent manner with an EC50 between 139-189 nM[1].


Teplinovivint (compound 175; 10 mg/ml; once daily for 21 days via topical application) causes amelioration of inflammation as well as tendon degeneration. Teplinovivint results in a decrease of aninflammatory plasma biomarker, KC/GRO in the Collagenase-induced Tendon Injury Model[1]. Teplinovivint (1 mg/ml with 1% BA) has a Tmax of 1 hours in plasma[1].


[1]. Vishal DESHMUKH, et al. Methods of using indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors. WO2018075858A1.

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