RO0270608

RO0270608，是 R411 的活性代谢物，是一种双重 alpha4beta1-alpha4beta7 (α4β1/α4β7) 整合素拮抗剂。具有抗炎活性。

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库存: 现货

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数量
5mg

￥3775.00

3020.00

- +
10mg

￥6262.00

5010.00

- +
25mg

￥11875.00

9500.00

- +
50mg

￥18162.00

14530.00

- +
100mg

￥27787.00

22230.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx33642
CAS: 220846-33-3
别名: (S)-2-(2-氯-6-甲基苯甲酰氨基)-3-(4-(2,6-二氯苯甲酰氨基)苯基)丙酸
分子式: C24H19Cl3N2O4
分子量: 505.78
纯度: >98%
溶解度:
储存: Store at -20°C
库存: 现货

Background

RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity[1][2].

RO0270608 inhibits α4/β7 mediated cell adhesion with an IC50 of 33 nM. In a human T-cell VCAM/anti CD3 costimulation assay RO0270608 causes a pronounced inhibition of T-cell proliferation (IC50=30 nM)[2].

In a murine OVA-model of airway inflammation, RO0270608 i.n. abolishes allergen-induced inflammatory cell accumulation[2]

[1]. Hijazi Y, et al. Pharmacokinetics, safety, and tolerability of R411, a dual alpha4beta1-alpha4beta7 integrin antagonist after oral administration at single and multiple once-daily ascending doses in healthy volunteers. J Clin Pharmacol. 2004;44(12):1368-1378.
[2]. M. Renzetti, et al. Dual α4/β1-α4/β7 vs α4/β1 selective antagonism is required for attenuation of allergic inflammatory responses. Journal of Allergy and Clinical Immunology. Volume 113, Issue 2, Supplement, February 2004, Page S221.