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- ATX inhibitor 5
ATX inhibitor 5
ATX inhibitor 5 是有效的口服活性 autotaxin (ATX) 抑制剂，IC50 为 15.3 nM。AATX inhibitor 5 具有抗肝纤维化作用，并显着降低 CCl4 诱导的肝纤维化水平。
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包装价格促销价数量
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5mg￥3775.003020.00- +
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10mg￥6262.005010.00- +
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25mg￥11875.009500.00- +
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50mg￥18162.0014530.00- +
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100mg￥26712.0021370.00- +
- 货号: ajcx33654
- CAS: 2402772-45-4
- 别名:
- 分子式: C22H18ClF3N6O
- 分子量: 474.87
- 纯度: ＞98%
- 溶解度: DMSO : 250 mg/mL (526.46 mM; Need ultrasonic)
- 储存: Store at -20°C
- 库存: 现货
Background
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently[1].
ATX inhibitor 5 (compound 10g) (IC50s=1.21 and 0.78 μM) displays activities against cardiac fibroblasts (CFs) and hepatic stellate cell (HSC)[1].ATX inhibitor 5 at 10 μM successfully suppresses collagen content induced by TGF-β[1].
ATX inhibitor 5 (20-40 mg/kg; p.o.; once daily for two weeks) reduces CCl4-induced hepatic fibrosis level prominently[1].
[1]. Jiang N, et al.Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis.Eur J Med Chem. 2020 Feb 1;187:111904.
