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- CCR (Chemokine receptors)
- BI-6901
BI-6901
BI-6901 是一种有效的选择性CCR10 拮抗剂 (pIC50=9.0)。BI-6901 对其他 GPCRs 表现出高选择性，包括许多其他趋化因子受体。BI-6901 对接触性超敏小鼠 DNFB 模型有效，可用于炎症研究。
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包装价格促销价数量
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5mg￥4100.003280.00- +
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10mg￥6475.005180.00- +
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25mg￥12287.009830.00- +
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50mg￥19237.0015390.00- +
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100mg￥30450.0024360.00- +
- 货号: ajcx33672
- CAS: 2040401-92-9
- 别名:
- 分子式: C23H27N5O3S
- 分子量: 453.56
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1].
BI-6901 (intraperitoneal injection; 100 mg/kg; bid.) exhibits a dose-dependent anti-inflammatory response against DNFB stimulated ear swelling in sensitized mice. The level of efficacy observed for BI-6901 is similar to that observed with anti-CCL27 antibody in the same model (60-85%)[1].
[1]. Asitha Abeywardane, et al. N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283.
