AG-270

A MAT2A inhibitor

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库存: 现货

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包装

价格

促销价

数量
5mg

￥3262.00

2610.00

- +
10mg

￥5175.00

4140.00

- +
25mg

￥9500.00

7600.00

- +
50mg

￥14962.00

11970.00

- +
100mg

￥24037.00

19230.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx33674
CAS: 2201056-66-6
别名:
分子式: C30H27N5O2
分子量: 489.57
纯度: >98%
溶解度: DMSO : 170 mg/mL (347.24 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

AG-270 is an inhibitor of methionine adenosyltransferase 2A (MAT2A; IC₅₀ = 0.014 ?M).¹ It reduces levels of S-(5'-adenosyl)-L-methonine in, and inhibits the proliferation of, HCT116 cells with a homozygous deletion of MTAP, the gene encoding methylthioadenosine phosphorylase (IC₅₀s = 0.2 and 0.257 ?M, respectively). AG-270 (200 mg/kg) reduces intratumor SAM levels and tumor growth in KP4 and HCT116 MTAP-null, but not HCT116 MTAP-wild-type, mouse xenograft models.

1.Konteatis, Z., Travins, J.G., S., Marjon, K., et al.Discovery of AG-270, a first-in-class oral MAT2A inhibitor for the treatment of tumors with homozygous MTAP deletionJ. Med. Chem.64(8)4430-4449(2021)