WEE1-IN-3

WEE1-IN-3 是一种有效的 Wee1 激酶抑制剂，其 IC50 <10 nM。WEE1-IN-3 具有抗癌活性。

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库存: 现货

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数量
5mg

￥4312.00

3450.00

- +
10mg

￥7337.00

5870.00

- +
25mg

￥14425.00

11540.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx33744
CAS: 2272976-28-8
别名:
分子式: C28H31N7O2
分子量: 497.59
纯度: >98%
溶解度: DMSO : 250 mg/mL (502.42 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. WEE1-IN-3 has anticancer activities[1].

WEE1-IN-3 (example 1) inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively[1].WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?Να repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types[1].

[1]. Peter Qinhua HUANG, et al. 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs. WO2019028008A1.