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ML359 is a small molecule inhibitor of protein disulfide isomerase (PDI).
ML359 is a small molecule inhibitor of protein disulfide isomerase (PDI).
ML359 shows no cytotoxicity in three human cell lines (HeLa, HEK293, and HepG2), and some activity in inhibiting platelet aggregation in vitro (25% inhibition at 30 ?M).[1]
ML359 inhibits of thrombus formation in a mouse laser injury model.[2]
[1] Carol Khodier, et al. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2013 Apr 12. [2] Bendapudi PK, et, al. Blood (2014) 124 (21): 2880.
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