DS-7423

DS-7423 是 PI3K 和 mTOR 的双抑制剂，其对 PI3Kα 和 mTOR 的IC50 值分别为15.6 nM 和 34.9 nM。DS-7423 具有抗癌活性。

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库存: 现货

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5mg

￥4850.00

3880.00

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10mg

￥8637.00

6910.00

- +
25mg

￥17625.00

14100.00

- +
50mg

￥27787.00

22230.00

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100mg

￥42750.00

34200.00

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Background

DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2].

DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1].DS-7423 also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM)[2].

[1]. Katsutoshi Oda, et al. Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. J Obstet Gynaecol Res. 2016 Jul;42(7):757-62.
[2]. Tomoko Kashiyama, et al. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014 Feb 4;9(2):e87220.