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- PD-1/PD-L1-IN-NP19
PD-1/PD-L1-IN-NP19
A PD-1/PD-L1 interaction inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥4100.003280.00- +
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10mg￥6475.005180.00- +
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25mg￥12287.009830.00- +
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50mg￥19237.0015390.00- +
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100mg￥30450.0024360.00- +
- 货号: ajcx33848
- CAS: 2377916-66-8
- 别名:
- 分子式: C33H31ClN2O4
- 分子量: 555.06
- 纯度: ＞98%
- 溶解度: DMSO : 6.25 mg/mL (11.26 mM; Need ultrasonic)
- 储存: Store at -20°C
- 库存: 现货
Background
NP19 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50 = 12.5 nM in a homogenous time-resolved fluorescence (HTRF) assay).1 It increases IFN-γ production by isolated human peripheral blood mononuclear cells (PBMCs) in co-culture with anti-CD3 single-chain variable fragment- and PD-L1-expressing Hep3B hepatoma cells (EC50 = ~3 ?M). NP19 (25, 50, and 100 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model and an H22 murine hepatocellular carcinoma model.
1.Cheng, B., Ren, Y., Niu, X., et al.Discovery of novel resorcinol dibenzyl ethers targeting the programmed cell death-1/programmed cell death-ligand 1 interaction as potential anticancer agentsJ. Med. Chem.63(15)8338-8358(2020)
