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  • PD-1/PD-L1-IN-NP19
PD-1/PD-L1-IN-NP19的可视化放大

PD-1/PD-L1-IN-NP19

A PD-1/PD-L1 interaction inhibitor

原价
¥4100-30450
价格
3280-24360
PD-1/PD-L1-IN-NP19的二维码

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  • 货号: ajcx33848
  • CAS: 2377916-66-8
  • 别名:
  • 分子式: C33H31ClN2O4
  • 分子量: 555.06
  • 纯度: >98%
  • 溶解度: DMSO : 6.25 mg/mL (11.26 mM; Need ultrasonic)
  • 储存: Store at -20°C
  • 库存: 现货

Background

NP19 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50 = 12.5 nM in a homogenous time-resolved fluorescence (HTRF) assay).1 It increases IFN-γ production by isolated human peripheral blood mononuclear cells (PBMCs) in co-culture with anti-CD3 single-chain variable fragment- and PD-L1-expressing Hep3B hepatoma cells (EC50 = ~3 ?M). NP19 (25, 50, and 100 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model and an H22 murine hepatocellular carcinoma model.


1.Cheng, B., Ren, Y., Niu, X., et al.Discovery of novel resorcinol dibenzyl ethers targeting the programmed cell death-1/programmed cell death-ligand 1 interaction as potential anticancer agentsJ. Med. Chem.63(15)8338-8358(2020)

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