XL177A

XL177A is a potent, selective and irreversible inhibitor of Ubiquitin specific peptidase 7 (USP7) with IC50 of 0.34?nM.

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库存: 现货

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5mg

￥2612.00

2090.00

- +
10mg

￥4100.00

3280.00

- +
25mg

￥8200.00

6560.00

- +
50mg

￥12925.00

10340.00

- +
100mg

￥21375.00

17100.00

- +

已选 0 种 0 瓶

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货号: ajcx33878
CAS: 2417089-74-6
别名:
分子式: C48H57ClN8O5
分子量: 861.47
纯度: >98%
溶解度: DMSO : 50 mg/mL (58.04 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

XL177A is a potent, selective and irreversible inhibitor of Ubiquitin specific peptidase 7 (USP7) with IC50 of 0.34?nM.

Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism: XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells.[1]

[1] Nathan J Schauer, et al. Sci Rep. 2020 Mar 24;10(1):5324.