DS-1205b free base

DS-1205b free base 是一种有效和选择性的 AXL 激酶抑制剂，IC50 值为 1.3 nM。DS-1205b free base 还可以抑制 MER，MET 和 TRKA，IC50 值分别为 63、104 和 407 nM。 DS-1205b free base 可以抑制细胞迁移和肿瘤生长。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥5937.00

4750.00

- +
10mg

￥10250.00

8200.00

- +
25mg

￥20837.00

16670.00

- +
50mg

￥34725.00

27780.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajcx34038
CAS: 1855860-24-0
别名:
分子式: C41H42FN5O7
分子量: 735.8
纯度: >98%
溶解度: DMSO : 50 mg/mL (67.95 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

DS-1205b free base is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205b free base also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205b free base can inhibit cell migration in vitro and tumor growth in vivo[1].

DS-1205b (0.3-33 μM; 2-24 h) inhibits hGAS6-induced migration in NIH3T3-AXL cells (EC50=2.7 nM)[1].DS-1205b (1-10000 μM; 2-24 h) significantly inhibits the phosphorylation of AXL in NIH3T3-AXL cells. DS-1205b decreases NIH3T3 cell proliferation but not obviously inhibits growth (GI50>10,000 nM)[1].

DS-1205b (3.1-50 mg/kg; p.o. bid for 5 d) exhibits pAXL inhibition mediated antitumor effects in mice[1].

[1]. Jimbo T, et, al. DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model. Oncotarget. 2019 Aug 27;10(50):5152-5167.