GSK-2793660
GSK-2793660（游离碱）是一种口服的、不可逆的组织蛋白酶 C (CTSC) 抑制剂。
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包装价格促销价数量
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5mg￥6687.005350.00- +
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10mg￥10575.008460.00- +
- 货号: ajcx34112
- CAS: 1613458-70-0
- 别名:
- 分子式: C20H27N3O3
- 分子量: 357.45
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
GSK-2793660 is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 can be used for the research of bronchiectasis[1][2].
GSK-2793660 is a cathepsin C (also known as dipeptidyl peptidase I enzyme) inhibitor for the reaearch of cystic fibrosis, non-cystic fibrosis bronchiectasis, anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis and bronchiectasis[1].
[1]. Szcze?niak P, et al. The Synthesis of α,α-Disubstituted α-Amino Acids via Ichikawa Rearrangement. J Org Chem. 2016 Feb 5;81(3):1057-74.
[2]. Miller BE, et al. Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660). Br J Clin Pharmacol. 2017 Dec;83(12):2813-2820.
