PD-1/PD-L1-IN 7

PD-1/PD-L1-IN 7 (PD-1/PD-L1-IN 7) 是一种人 PD-1/PD-L1 蛋白/蛋白相互作用抑制剂，IC50 为 0.213 nM。

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库存: 现货

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5mg

￥5175.00

4140.00

- +
10mg

￥8637.00

6910.00

- +
25mg

￥17625.00

14100.00

- +
50mg

￥27250.00

21800.00

- +

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货号: ajcx34160
CAS: 2374856-75-2
别名: PD-1/PD-L1-IN 7
分子式: C34H36Cl2N8O4
分子量: 691.61
纯度: >98%
溶解度: DMSO : 50 mg/mL (72.30 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

PD-1/PD-L1-IN 7 is a human PD-1/PD-L1 protein/protein interaction inhibitor with an IC50 of 0.213 nM. PD-1/PD-L1-IN 7 has anticancer and antiviral functions[1].

PD-1/PD-L1-IN 7 (compound 139) enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. PD-1/PD-L1-IN 7 also enhances the frequency of GrB+ cells among HBV-specific CD8+ and CD4+ T cells. The ability of PD-1/PD-L1-IN 7 to enhance the antiviral functions of HBV-specific CD8+ and CD4+ T cells in vitro is comparable to those of Durvalumab[1].

PD-1/PD-L1-IN 7 (Compound 139; 10-50 mg/kg; intraperitoneal injection, daily, for 6 days) treatment shows >90% PD-L1 target occupancy (TO) on the tumor cells. PD-1/PD-L1-IN 7 significantly inhibits tumor growth in a human PD-L1 expressing MC38 mouse colorectal tumor model[1].

[1]. Evangelos Aktoudianakis, et al. Pd-1/pd-l1 inhibitors. WO2019160882A1.