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- PKD (Protein kinase D)
- PROTAC EED degrader-2
PROTAC EED degrader-2
PROTAC EED degrader-2 是靶向 EED 的 PROTAC 分子，pKD 为 9.27。PROTAC EED degrader-2 是靶向 EED 亚基的多梳抑制复合物 2 (PRC2) 抑制剂 (pIC50=8.11)。
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包装价格促销价数量
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5mg￥10250.008200.00- +
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10mg￥17625.0014100.00- +
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25mg￥36862.0029490.00- +
- 货号: ajcx34276
- CAS: 2639882-69-0
- 别名:
- 分子式: C50H58FN11O6S
- 分子量: 960.13
- 纯度: ＞98%
- 溶解度: DMSO : 100 mg/mL (104.15 mM; Need ultrasonic)
- 储存: 4°C, protect from light
- 库存: 现货
Background
PROTAC EED degrader-2 is a PROTAC targeting EED with a pKD of 9.27. PROTAC EED degrader-2 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.11) targeting the EED subunit[1].
PROTAC EED degrader-2 (Compound PROTAC 1) binds to EED with a pKD of 9.27±0.05 and inhibits PRC2 function with a pIC50 of 8.11±0.09[1]. PROTAC EED degrader-2 (0.01-100 μM; 14 days) can potently inhibit proliferation of an EZH2 mutant DLBCL cell line Karpas422[1]. PROTAC EED degrader-2 (0.1-3 μM; 48 hours) reduces the protein levels of EED, EZH2, H3K27me3 in Karpas422 cells[1].PROTAC EED degrader-2 (1 μM ; 1-24 h) promotes degradation of EED, EZH2, and SUZ12 in Karpas422 cells[1].
[1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.
