AZD1940

AZD1940 是一种具有口服活性，高亲和力的大麻素 CB1/CB2 受体激动剂，对 CB1R 和 CB2R 的 pKi 值分别为 7.93 和 9.06，并具有强大的镇痛作用。

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库存: 现货

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1mg

￥1737.00

1390.00

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5mg

￥4312.00

3450.00

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10mg

￥7337.00

5870.00

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货号: ajcx34544
CAS: 881413-29-2
别名:
分子式: C20H29F2N3O2S
分子量: 413.52
纯度: >98%
溶解度: DMSO : 100 mg/mL (241.83 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

AZD1940 is an orally active, high affinity cannabinoid CB1/CB2 receptor agonist with pKi values of 7.93 and 9.06 for human CB1R and CB2R, respectively. AZD1940 shows a robust analgesia action[1][2].

AZD1940 binds with high affinity to human, rat and mouse CB1 and CB2 receptors and displays full agonism at both receptors in all three species[1][2].

When given orally to rats, AZD1940 produces a robust analgesia in different models of inflammatory and neuropathic pain[1][2].For AZD1940, low brain uptake at analgesic doses has been demonstrated in both rats and primates[1].

[1]. Jarkko Kalliom?ki, et al. Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia. Clin Exp Pharmacol Physiol. 2013 Mar;40(3):212-8.
[2]. Magnus Schou, et al. Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate. Nucl Med Biol. 2013 Apr;40(3):410-4.