Bakkenolide B 是从 petasites japonicas 叶片中分离出来的，具有抗过敏和抗炎作用。 Bakkenolide B 可用于研究哮喘。
Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma[1].
Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner[1].Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages[1].
Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice[1].
[1]. Lee KP, et al. Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves.J Ethnopharmacol. 2013 Jul 30;148(3):890-4.
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