CDK4-IN-1-d6
CDK4-IN-1-d6 是一种 CDK4-IN-1 氘代物。CDK4-IN-1 (compound 63) 是一种 CDK4 抑制剂 (IC50= 10 nM)。
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包装价格促销价数量
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1mg￥4850.003880.00- +
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5mg￥13350.0010680.00- +
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- 货号: ajcx34618
- CAS: N/A
- 别名:
- 分子式: C22H23D6ClN8
- 分子量: 447.01
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
CDK4-IN-1-d6 is a deuterium labeled CDK4-IN-1. CDK4-IN-1 (compound 63) is a CDK4 inhibitor (IC50= 10 nM)[1].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[1].
[1]. Cho YS, Borland M, Brain C, et al. 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J Med Chem. 2010;53(22):7938-7957.
[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
