Crocin IV (Dicrocin) 是一种藏红花苷糖苷，一种类胡萝卜素色素。Crocin IV 具有强大的抗氧化活性。
Crocin IV (Dicrocin), a crocetin glycoside, is a carotenoid pigment. Crocin IV has potent antioxidant activity[1].
Crocin IV (Dicrocin; 10 μM; 24 hours) has little or no effect on the prolongation of cell survival in PC12 cell[1]. Crocin IV enhances γ-GCS mRNA expression in serum-deprived and hypoxic PC12 cells[1]. Measurements of cell viability, peroxidized membrane lipids and caspase-3 activity showed that the rank order of the neuroprotective potency at a concentration of 10 μM is crocin>tricrocin>dicrocin and picrocrocin (the latter two crocins had a little or no potency)[1].
[1]. Takashi Ochiai, et al. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta. 2007 Apr;1770(4):578-84.
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