DP-C-4
DP-C-4 是一种基于 Cereblon 的双 PROTAC，用于同时降解 EGFR 和 PARP。
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包装价格促销价数量
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1mg￥3050.002440.00- +
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5mg￥9175.007340.00- +
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10mg￥14425.0011540.00- +
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- 货号: ajcx34710
- CAS: N/A
- 别名:
- 分子式: C72H78ClF2N15O14
- 分子量: 1450.93
- 纯度: ＞98%
- 溶解度: DMSO : 12 mg/mL (8.27 mM; Need ultrasonic)
- 储存: -80°C, stored under nitrogen
- 库存: 现货
Background
DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].
DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1].
[1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.
