Erlotinib-13C6
Erlotinib-13C6 (CP-358774-13C6) 是一种 13C 标记的 Erlotinib。Erlotinib 是一种直接作用的 EGFR 酪氨酸激酶抑制剂，对人 EGFR 的 IC50 为 2 nM。
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包装价格促销价数量
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1mg￥16562.0013250.00- +
- 货号: ajcx34742
- CAS: 1211107-68-4
- 别名: CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6
- 分子式: C16 13C6H23N3O4
- 分子量: 399.39
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].
Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2].
[1]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57(21), 4838-4848.
[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
