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- F13714 fumarate
F13714 fumarate
F13714 fumarate 是一种选择性 5-HT1A 受体偏向激动剂，在慢性轻度应激小鼠模型中单次给药后具有抗抑郁样特性。
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包装价格促销价数量
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5mg￥3050.002440.00- +
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10mg￥4962.003970.00- +
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25mg￥9175.007340.00- +
- 货号: ajcx34760
- CAS: 208109-39-1
- 别名: F 14679 fumarate
- 分子式: C25H29ClF2N4O5
- 分子量: 538.97
- 纯度: ＞98%
- 溶解度: DMSO : 250 mg/mL (463.85 mM; Need ultrasonic)
- 储存: Store at -20°C
- 库存: 现货
Background
F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress[1].
F13714 targets 5-HT1A autoreceptors[1].
In UCMS mice, a single administration of F13714 (4-16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels[1]. F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%[1].F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement[1]. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in na?ve rats[1].
[1]. Monika G?uch-Lutwin, et al. The selective 5-HT 1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress. Psychopharmacology (Berl). 2021 May 10.
