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- m-PEG12-Thiol
m-PEG12-Thiol
m-PEG12-Thiol 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。
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包装价格促销价数量
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50mg￥1775.001420.00- +
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100mg￥2725.002180.00- +
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250mg￥4525.003620.00- +
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- 货号: ajcx34974
- CAS: 2413368-61-1
- 别名:
- 分子式: C25H52O12S
- 分子量: 576.74
- 纯度: ＞98%
- 溶解度: DMSO : 100 mg/mL (173.39 mM; Need ultrasonic)
- 储存: Store at -20°C, sealed storage, away from moisture and light
- 库存: 现货
Background
m-PEG12-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
