MSN-50
MSN-50 是一种 Bax 和 Bak 寡聚抑制剂。MSN-50 能有效抑制脂质体的通透性，防止基因毒性细胞死亡，促进神经保护。
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包装价格促销价数量
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5mg￥10575.008460.00- +
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10mg￥16562.0013250.00- +
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25mg￥32587.0026070.00- +
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50mg￥52150.0041720.00- +
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100mg￥83362.0066690.00- +
- 货号: ajcx34986
- CAS: 1592908-75-2
- 别名:
- 分子式: C36H38BrN3O6
- 分子量: 688.61
- 纯度: ＞98%
- 溶解度: DMSO : 200 mg/mL (290.44 mM; Need ultrasonic)
- 储存: 4°C, stored under nitrogen, away from moisture
- 库存: 现货
Background
MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection[1][2].
MSN-50 (0~10 uM) inhibits dye release from liposomes in a concentration-dependent fashion. MSN-50 (0~40 uM) inhibits tBid/Bax-mediated MOMP (mitochondrial outer membrane permeabilization) in a concentration-dependent manner and shows concentration-dependent inhibition of Bak-mediated MOMP. MSN-50 inhibits both Bax and Bak after activation by either cBid or Bim. MSN-50 (5 μM; BMK cells) inhibits apoptosis induced by actinomycin D and staurosporin (STS)[1][2].
[1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017;24(4):493-506.e5.
[2]. Jensen K, et al. Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax. Exp Biol Med (Maywood). 2019;244(8):621-629.
