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  • Norverapamil D7 hydrochloride
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Norverapamil D7 hydrochloride

Norverapamil D7 ((±)-Norverapamil D7) hydrochloride 是一种 Norverapamil 氘代物。Norverapamil ((±)-Norverapamil) 是 Verapamil 的 N-去甲基代谢物,也是一种L型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。

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Norverapamil D7 hydrochloride的二维码
  • 库存: 现货
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  • 1mg
    ¥2062.00
    1650.00
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    ¥7225.00
    5780.00
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  • 货号: ajcx35050
  • CAS: 1216413-74-9
  • 别名: (±)-Norverapamil-d7 hydrochloride; D591-d7 hydrochloride
  • 分子式: C26H30D7ClN2O4
  • 分子量: 484.08
  • 纯度: >98%
  • 溶解度:
  • 储存: Store at -20°C
  • 库存: 现货

Background

Norverapamil D7 ((±)-Norverapamil D7) hydrochloride is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].


Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[3].


[1]. Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66.
[2]. Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82.
[3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

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