NV-5138
A sestrin modulator and mTORC1 activator
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包装价格促销价数量
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5mg￥2725.002180.00- +
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10mg￥4312.003450.00- +
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25mg￥9175.007340.00- +
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50mg￥14425.0011540.00- +
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100mg￥20837.0016670.00- +
- 货号: ajcx35056
- CAS: 2095886-80-7
- 别名:
- 分子式: C7H13F2NO2
- 分子量: 181.18
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C,unstable in solution, ready to use.
- 库存: 现货
Background
NV-5138 is a sestrin modulator and mammalian target of rapamycin protein complex 1 (mTORC1) activator.1 It binds to sestrin 2 (Kd = 1.49 ?M) and induces dissociation of sestrin 2 from the multimeric mTORC1 inhibitory complex GATOR2 and mTORC1 activation when used at concentrations ranging from 30 to 100 ?M. NV-5138 (40, 80, or 160 mg/kg) reduces immobility time in the forced swim test and latency to feed in the novelty-suppressed feeding test, indicating antidepressant- and anxiolytic-like activity, respectively, in rats, effects that can be reversed by the mTORC1 inhibitor rapamycin .2 It also reverses behavioral and synaptic deficits in a rat model of chronic stress-induced depression.
1.Sengupta, S., Giaime, E., Narayan, S., et al.Discovery of NV-5138, the first selective Brain mTORC1 activatorSci. Rep.9(1)4107(2019) 2.Kato, T., Pothula, S., Liu, R.-J., et al.Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activationJ. Clin. Invest.129(6)2542-2554(2019)
