An ASBT inhibitor
Odevixibat is an inhibitor of the sodium/bile acid and sulfated solute cotransporter (ASBT; IC50 = 0.16 nM).1 It inhibits intestinal reabsorption of [75Se]homotaurocholic acid (75SeHCAT) by 74% in ApoE-/- mice when administered at a dose of 0.156 ?mol/kg. Formulations containing odevixibat have been used in the treatment of pruritis in patients with progressive familial intrahepatic cholestasis, an inborn error of metabolism characterized by mutations in various genes involved in bile production and transport, including ATP8B1 and ABCB11.
1.Gillberg, P.-G., Graffner, H., and Ingemar, S.IBAT inhibitors for the treatment of liver disease(2017)
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