Odevixibat

An ASBT inhibitor

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库存: 现货

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包装

价格

促销价

数量
5mg

￥1262.00

1010.00

- +
10mg

￥2112.00

1690.00

- +
25mg

￥3775.00

3020.00

- +
50mg

￥6300.00

5040.00

- +
100mg

￥10500.00

8400.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx35066
CAS: 501692-44-0
别名: A4250
分子式: C37H48N4O8S2
分子量: 740.93
纯度: >98%
溶解度: DMSO : 166.67 mg/mL (224.95 mM; Need ultrasonic)
储存: Store at -20°C, stored under nitrogen
库存: 现货

Background

Odevixibat is an inhibitor of the sodium/bile acid and sulfated solute cotransporter (ASBT; IC₅₀ = 0.16 nM).¹ It inhibits intestinal reabsorption of [⁷⁵Se]homotaurocholic acid (⁷⁵SeHCAT) by 74% in ApoE^-/- mice when administered at a dose of 0.156 ?mol/kg. Formulations containing odevixibat have been used in the treatment of pruritis in patients with progressive familial intrahepatic cholestasis, an inborn error of metabolism characterized by mutations in various genes involved in bile production and transport, including ATP8B1 and ABCB11.

1.Gillberg, P.-G., Graffner, H., and Ingemar, S.IBAT inhibitors for the treatment of liver disease(2017)