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- PW0464
PW0464
PW0464 是一种纳摩尔有效的完全 G 蛋白偏向配体，是一种非儿茶酚 D1R 激动剂，EC50 为 5.8 nM (Gs-cAMP)。
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包装价格促销价数量
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5mg￥5175.004140.00- +
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10mg￥8637.006910.00- +
- 货号: ajcx35128
- CAS: 1643462-93-4
- 别名: PW0464
- 分子式: C19H17F2N3O4
- 分子量: 389.35
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP)[1].
PW0464 (compound 24) is found to elicit complete G protein bias, showing no activity for D1R-mediated β-arrestin recruitment[1].PW0464 (compound 24), the non-catechol agonist, forms bonds with S1985.42 and S2025.46 via its fluorine atom[2].
[1]. Pingyuan Wang, et al. Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. ACS Med Chem Lett
[2]. David R Sibley, et al. Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential. Signal Transduct Target Ther. 2021 May 22;6(1):205.
